Anti-Aging Vaccine Developed By Japanese Scientists
An anti-aging vaccine has been discovered, according to recent research by Japanese scientists, and it is claimed to eradicate zombie cells that collect with age and destroy neighboring cells, producing aging-related disorders such as arterial stiffening, as well as increase human longevity.
Author:Stefano MclaughlinReviewer:Karan EmeryFeb 20, 202265.5K Shares1.1M Views
An anti-aging vaccine has been discovered, according to recent research by Japanese scientists, and it is claimed to eradicate zombie cells that collect with age and destroy neighboring cells, producing aging-related disorders such as arterial stiffening, as well as increase human longevity.
Researchers from Tokyo's Juntendo University found that mice given the vaccine had less senescent cells, often known as zombie cells, and had less arterial stiffening in areas impacted by arterial stiffening.
According to Professor Toru Minamino, one of the researchers, the vaccine will be used to treat arterial stiffness, diabetes, and other aging-related disorders.
Senescent cells are ones that have ceased to divide but have not died. They create inflammation in neighboring healthy cells by releasing substances that harm them.
Telomere degradation is the most well-known cause of senescent cells. Telomeres are DNA sequences that can be found at the ends of chromosomes. They are made up of a DNA sequence of repeated nucleotides; for example, in human telomeres, the repeated nucleotides are TTAGGG, and they stretch to 11 kilobases after birth. These repetitions prevent the chromosomes from losing essential information and combining with adjacent chromosomes during replication.
Other types of DNA damage, in addition to telomere erosion, can cause cellular senescence by degrading DNA. DNA double strand breaks are the most common cause of DDR (DNA damage response), which causes cells to become senescent. The presence of mitogenic signals, reactive oxygen species, or specific proteins that stimulate cell growth and proliferation are examples of other factors that act through the DDR.
The researchers discovered a protein found in senescent cells in humans and mice, and developed a peptide vaccination based on one of the protein's amino acids.
The vaccine causes the body to produce antibodies that bind to senescent cells and are then eliminated by white blood cells that stick to the antibodies.
Many accumulated senescent cells were eliminated and disease-affected areas reduced when the team gave the vaccine to animals with arterial stiffness. According to the researchers, when given to elderly mice, the frailty progression was slower than in uninfected mice.
Many of the currently available medications for removing senescent cells are also used as anti-cancer treatments and may have undesirable side effects. The new vaccine had fewer side effects and lasted longer, according to the researchers.
The vaccination also successfully targeted senescent cells in adipose tissue and blood arteries, implying that it could benefit other age-related medical disorders.
Stefano Mclaughlin
Author
Stefano Mclaughlin is a Psychologist focused on mental health, emotional well-being, and healthcare policy. He studied Psychology and Public Health at the University of Massachusetts Amherst, gaining a deep understanding of the intersection between mental health and public policy.
Stefano's mission is clear: he aims to destigmatize mental health discussions, improve access to mental healthcare, and promote emotional well-being for all. Drawing from personal experiences with anxiety and depression, Stefano shares real stories to make mental health topics more relatable and less intimidating.
In addition to his advocacy work, Stefano enjoys delving into books, experimenting in the kitchen, and embarking on new adventures. These hobbies fuel his creativity and inspire fresh perspectives for his advocacy work.
Karan Emery
Reviewer
Karan Emery, an accomplished researcher and leader in health sciences, biotechnology, and pharmaceuticals, brings over two decades of experience to the table. Holding a Ph.D. in Pharmaceutical Sciences from Stanford University, Karan's credentials underscore her authority in the field.
With a track record of groundbreaking research and numerous peer-reviewed publications in prestigious journals, Karan's expertise is widely recognized in the scientific community.
Her writing style is characterized by its clarity and meticulous attention to detail, making complex scientific concepts accessible to a broad audience. Apart from her professional endeavors, Karan enjoys cooking, learning about different cultures and languages, watching documentaries, and visiting historical landmarks.
Committed to advancing knowledge and improving health outcomes, Karan Emery continues to make significant contributions to the fields of health, biotechnology, and pharmaceuticals.
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