Infection is the most common cause of fever in hemodialysis patients, with malignancy and autoimmune disorders being less common. That's why a lot of patients undergoing dialysis as part of their health and well-being maintenance are asking: is fever normal after dialysis? Sometimes, despite empirical treatment, fever persists, and investigations into the aforementioned diagnoses fail to reveal the cause. Thus, rarer etiologies must be considered, which may appear rather unexpected, especially in patients who have been under medical supervision for a long time.